TGF-?: a mobile purveyor of immune privilege
نویسندگان
چکیده
منابع مشابه
Immune Privilege
T he concept of immune privilege refers to the observation that tissue grafts placed in certain anatomical sites, including the brain and eye, can survive for extended periods of time (1). Immune privilege is thought to reflect an evolutionary adaptation to protect vital structures from damage by inflammatory responses directed against pathogens. It was originally believed that antigens in immu...
متن کاملA novel role for TGF-beta and IL-10 in the induction of immune privilege.
Immune privilege within the eye is due in large part to Ag-specific, systemic down-regulation of Th1 immune responses, a phenomenon termed anterior chamber-associated immune deviation (ACAID). Since the cytokine milieu influences Th cell differentiation, we hypothesized that TGF-beta, an immunosuppressive cytokine secreted by ocular cells, determines the nature of the immune response to Ags int...
متن کاملMechanism of Immune Privilege
The eye is a privileged site that cannot tolerate destructive inflammatory responses. Inflammatory cells entering the anterior chamber of the eye in response to viral infection underwent apoptosis that was dependent on Fas (CD95)-Fas ligand (FasL) and produced no tissue damage. In contrast, viral infection in gid mice, which lack functional FasL, resulted in an inflammation and invasion of ocul...
متن کاملOcular immune privilege
The eye attempts to limit local immune and inflammatory responses to preserve vision. This phenomenon, known as ocular immune privilege, is mediated by a combination of local and systemic mechanisms. While immune privilege is believed to protect the eye from day-to-day inflammatory insults, it is not absolute and its mechanisms are still incompletely understood.
متن کاملPrivilege Management of Mobile Agents
Most mobile agent systems use internal data structures within an agent to control and specify its security requirements and properties. These structures typically contain authorization information regarding access to computational resources on distributed systems and conceptually serve as an internal passport for the agent. While these structures are often very similar semantically, they differ...
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ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2006
ISSN: 0105-2896,1600-065X
DOI: 10.1111/j.1600-065x.2006.00437.x